RT info:eu-repo/semantics/bachelorThesis
T1 Factores genéticos implicados en la susceptibilidad y gravedad de la COVID-19
A1 Adrián González, Noelia
A2 Grado En Farmacia
K1 COVID-19
K1 SARS-CoV-2
K1 GWAS
K1 Susceptibilidad genética
AB Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an emerging pathogen that has caused a global pandemic due to the Coronavirus Disease 2019 (COVID-19). This disease displays a highly variable clinical picture that ranges from asymptomatic disease to more severe disease such as pneumonia, hypoxia and severe respiratory distress, to the most critical disease with respiratory failure, sepsis, septic shock and/or multi-organ failure that can lead to death. COVID-19 is associated with several risk factors such as distinct ethnicity/race, sex, age, pre-existing comorbidities, and genetics factors. It is likely that a mixture of genetic and non-genetic factors interplays between virus and host genetics, and determines the severity of disease outcome.  In this work, a bibliography search has been carried out in order to identify the most important genes and genetic variants associated with increased susceptibility and severity of COVID‐19. Our findings highlight genetic variation in the ABO, HLA, OAS, DPP9, TYK2, TMEM189-UBE2V1, IFNAR2 and TMPRSS2 genes, as well as the 3p21.31 locus (harboring LZTFL1 and CXCR6, among others). Moreover, we describe the functional evidence that supports their implication in COVID-19.
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/29966
UL http://riull.ull.es/xmlui/handle/915/29966
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 31-dic-2024