RT info:eu-repo/semantics/article
T1 Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity
A1 Lorenzo-Luis, Pablo
A1 Alguacil, Andrés
A1 Scalambra, Franco
A1 Puerta, Adrián
A1 Gonzalez Bakker, Aday
A1 Mendoza, Zenaida
A1 Padrón, José M.
A1 Romerosa, Antonio
A2 Química
A2 Área de Química Inorgánica-CIESOLUniversidad de Almería, 04120 Almería, Spain. E-mail: romerosa@ual.es
BioLab, Instituto Universitario de Bio-Orgánica ¿Antonio Gónzalez¿, Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38071 La Laguna, Spain
cÁrea de Química Inorgánica, Departamento
AB Complexes [{RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2-N,N’-CuCl}2-µ-Cl-µOCH3](CF3SO3)2·(CH3OH)4 (1) and [{RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2-N,N’-NiCl}2-µ-Cl-µ-OH](CF3SO3)2 (2) have been synthesized andcharacterized. Their antiproliferative activities were assessed againstsix human solid tumours showing nanomolar GI50 values. The effectsof 1 and 2 on SW1573 cells colony formation, HeLa cells actionmechanism and their interaction with the pBR322 DNA plasmid wereevaluated.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/34772
UL http://riull.ull.es/xmlui/handle/915/34772
LA en
NO DOI: 10.1039/d3dt01284k
DS Repositorio institucional de la Universidad de La Laguna
RD 08-may-2024