RT info:eu-repo/semantics/article
T1 Tocilizumab-related hypertriglyceridemia is independent of key molecules regulating lipid metabolism
A1 Castro Hernández, Javier Rafael
A1 Ferraz Amaro, Iván
A1 Santos Concepción, Sergio
A1 Hernández Hernández, María V.
A1 Tejera Segura, Beatriz
A1 Luna, Cristina
A1 Delgado Frias, Esmeralda
A1 Díaz González, Federico
A2 Medicina Física y Farmacología
K1 rheumatoid arthritis
K1 tocilizumab
K1 tryglicerides
AB Introduction: Tocilizumab (TCZ) treatment is associated with dyslipidaemia,including a rise in triglycerides through a mechanism poorly understood. Threemolecules play key roles in the regulation of triglyceride metabolism: apolipoprotein C-III (ApoC-III), angiopoietin-like protein 4(ANGPLT4) and lipoproteinlipase (LPL). The aim of this work was to analyse whether the changes in triglycerides shown by TCZ-treated RA patients could stem from the dysregulation thatcan occur in these regulatory molecules.Methods: Twenty-seven RA patients included in the TOCRIVAR study who received TCZ (8mg/kg IV/q4w) were evaluated at baseline and at Weeks 12, 24 and52 of treatment. ANGPTL4, ApoC-III and LPL, a complete lipid profile and RAdisease activity, were analysed at baseline and at each visit. Multivariable linearmixed models were performed to study changes over time in lipids and regulatorymolecules.Results: After 24weeks of TCZ treatment, HDL cholesterol, apolipoprotein A1and triglycerides increased, whereas lipoprotein (a) decreased significantly frombaseline values. However, 1 year after TCZ, no significant differences in lipid pattern were observed with respect to baseline. Serum ANGPTL4 and Apo-CIII levels decreased gradually over time, both being significantly lower than baselinevalues at Week 52. LPL concentration did not change significantly during TCZtreatment. Remarkably, the elevation of triglycerides at Week 24 maintained itsstatistical significance after adjusting for the changes in ApoC-III, ANGPTL4 andLPL.Conclusion: In TCZ-treated RA patients basal serum levels of ANGPLT4 andApoC-III, but not LPL, decreased significantly. However, the elevation of triglycerides after TCZ was not related to changes in these regulatory molecules.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/34775
UL http://riull.ull.es/xmlui/handle/915/34775
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 11-jul-2024