RT info:eu-repo/semantics/article
T1 The Impact of MRSA Colonization on Healthcare-Associated
Infections in Long-Term Care Facility Residents:
A Whole-Genome Sequencing-Based Study
A1 Arias Rodríguez, María de los Ángeles
A1 Callejón Fernández, Manuel
A1 Abreu Rodríguez, Rossana
A1 Arias, Ángeles
A1 Aguirre-Jaime, Armando
A1 Castro Hernández, María Beatriz
A1 Ramos Real, María José
A1 Pedroso Fernández, Yanet
A1 Lecuona, María
K1 MRSA
K1 long-term care facilities
K1 colonization
K1 infection
K1 prevalence
K1 whole-genome sequencing
AB Methicillin-resistant Staphylococcus aureus (MRSA) colonization has been considered arisk factor for the development of infection, however, there are no studies that have compared thecolonizing and infecting strains using whole-genome sequencing (WGS). The aim of this study is todetermine the prevalence of and risk factors for MRSA colonization among long-term care facilities(LTCF) residents of Tenerife (Spain), and to analyze the epidemiological relationship between thecolonizing and infecting strains using WGS. A point-prevalence study was carried out at 14 LTCFsin Tenerife from October 2020 to May 2021. Nasal swabs were cultured for MRSA. Colonizedresidents were followed up for two years. A phylogenetic comparison between colonization andinfection strains was performed using WGS. A total of 764 residents were included. The prevalenceof colonization by MRSA was 28.1% (n = 215), of which 12 (5.6%) subsequently developed infection.A close genetic relationship between colonization and infection isolates was found in three of thefour (75%) residents studied. Our study confirms that colonized residents can develop seriousMRSA infections from the same nasal colonization strain. Given the high prevalence of MRSAcolonization in these centers, it is necessary to implement strategies with preventive measures toavoid the development of infection and the transmission of MRSA.
SN 2076-2607
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/34820
UL http://riull.ull.es/xmlui/handle/915/34820
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 24-nov-2024