RT info:eu-repo/semantics/article
T1 Structure-function correlation using OCT angiography and microperimetry in diabetic retinopathy
A1 Gómez Culebras, Mario  Alberto
A1 Alonso Plasencia, Marta
A1 Abreu-González, Rodrigo
A2 Cirugía
K1 diabetic retinopathy
K1 vessel density
K1 retinal sensitivity
AB Purpose: To evaluate macular vasculature in diabetic retinopathy (DR) with optical coherence tomography angiography (OCTA) and to correlate vessel density (VD) with retinalsensitivity (RS) as a way to assess structural and functional findings in DR.Design: Prospective observational cross-sectional study.Methods: Diabetic patients with DR but no clinically significant diabetic macular edema(DME) and healthy subjects were included in this study. All of them underwent comprehensive ophthalmic examination, best corrected visual acuity (BCVA), OCTA with RS-3000Advance AngioScan (Nidek, Gamagori, Japan) and microperimetry with MP-3 (Nidek,Gamagori, Japan). Retinal vascular density measured by OCT angiography in 9 areas wascorrelated with RS in the same 9 areas by Spearman correlation.Results: In this study, 50 subjects were enrolled: 25 eyes of diabetic patients with DR and 25eyes of non-diabetic subjects. Diabetic patients mean age was 51.88±13.62 years; nondiabetic subjects were 43.48±13.42 years. The BCVA was 20/25 in the diabetic group and20/20 in the non-diabetic group. Mean RS was decreased in the DR group (27.68±2.71 dB)compared to the non-diabetic group (31.68±1.46 dB) (p<0.05) and in the 9 studied areas(p<0.05). Mean VD was decreased in the DR group compared to non-diabetics (p<0.05) andin 7 of the 9 areas (except temporal superior and inferior squares) (p<0.05). Correlations byareas between VD and RS were assessed, we found moderate correlation in the area temporalto the fovea (r=0.501, p=0.01) in the DR group but not in the non-diabetic subjects. Therewere no other statistical significant correlations with this pattern.Conclusion: DR without DME results in a retinal VD decreased that might be the cause ofa reduction of RS in one of the studied areas. Microangiopathic changes are correlated withmicroperimetry sensitivity drop in the temporal to the fovea grid but not in the otherstudied grids
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/34835
UL http://riull.ull.es/xmlui/handle/915/34835
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DS Repositorio institucional de la Universidad de La Laguna
RD 27-dic-2024