RT info:eu-repo/semantics/article
T1 Ferritin, serum iron and hemoglobin as acute phase reactants in laparoscopic and open surgery of cholecystectomy: An
observational prospective study
A1 Martínez Riera, Antonio María
A1 Vila Zárate, Cristina
A1 Martín González, Candelaria
A1 González Álvarez, Ruimán José
A1 Soto Darias, Iván
A1 Díaz Pérez, Beatriz
A1 Abreu González, Pedro
A1 Medina Arana, Vicente
K1 inflammatory response
K1 acute phase reactants
K1 cytokines
K1 ferritin
K1 N/L ratio
K1 interleukin 6
K1 CRP
K1 hemoglobin
AB Cytokines are expressed by various cells after several stimuli such as surgical tissue damage, producing a systemic inflammatory response (SIR). C-reactive protein (CRP) is used extensively in clinical practice after operative injury, but proinflammatory cytokines, iron status, albumin, neutrophil-to-lymphocyte (N/L) ratio and hemoglobin, as acute phase reactants, have beenpoorly documented. This study aims to show how they behave after surgery, comparing laparoscopic (LC) versus open cholecystectomy (OC). In total, 55 patients were included in a prospectivenon-randomized form to undergo a cholecystectomy: 8 patients OC (50% females) and 47 patientsLC (68% females). Before (A1) and 24 h after surgery (A2), blood samples were taken for an ordinaryanalysis and IL6, IL8 and TNFα determination. There were no differences between LC and OCgroups concerning age, CRP, IL6 and TNFα at day A1. In the LC group at day A2, CRP, IL6, IL8,TNF, ferritin, leukocytes and N/L ratio increased; hemoglobin, lymphocytes, prothrombin and albumin decreased (p < 0.05). In the OC group at day A2, only IL6 (p < 0,07), ferritin, leukocytes, N/Lratio and CRP (p < 0.05) increased; serum iron, hemoglobin, lymphocytes and albumin (p < 0.05)decreased. At day A2, OC vs. LC group, higher values were observed in IL6, ferritin and CRP (p ≤0.05), and lesser values were observed in serum iron and prothrombin (p < 0.05). In conclusion,classic markers of inflammation are altered after surgery, in a milder way in laparoscopic surgery.Ferritin can be used as an inflammatory marker, as has been described in COVID-19 infection.
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/34846
UL http://riull.ull.es/xmlui/handle/915/34846
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 08-jul-2024