RT info:eu-repo/semantics/article
T1 Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy
A1 Barrios del Pino, Yvelise
A1 Poza-Guedes, Paloma
A1 Fuentes, Victoria
A1 Franco, A.
A1 Sánchez-Machín, Inmaculada
A1 Alonso, E.
A1 González Pérez, R.
A1 Infante, S.
A1 Zapatero, L.
A1 Matheu, Víctor
AB Background. Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy. Methods. We design a prospective longitudinal study (n=30) with patients with persistent cow's milk proteins (CMP) allergy. After achieving a CMP rush desensitization protocol, a clinical followup including SPT and blood samples to determine sIgE, protein levels, PDGF, and VEGF-A and a panel of the most representative Th1, Th2, Treg, and Th17 cytokines were also monitored. Results. Baseline levels of PDGF and VEGF in the CMP allergic patients (1170 pg/mL and 253 pg/mL) were different compared to those nonallergic CMP control subjects (501 pg/mL and 108 pg/mL). Both PDGF and VEGF were significantly downregulated (P<0.05) 6 months after completion of the CMP desensitization process and remained significantly decreased 12 months later. Conclusion. The present study shows a significant increase of PDGF and VEGF in anaphylaxis suffering children compared to a control group. Interestingly, both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization
SN 2314-6141
YR 2014
FD 2014
LK http://riull.ull.es/xmlui/handle/915/34878
UL http://riull.ull.es/xmlui/handle/915/34878
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 25-nov-2024