RT info:eu-repo/semantics/article
T1 Severe cutaneous vasculitis following intravenous infusion of gammagloubin in a patient with type II mixed cyroglobulinemia
A1 Barrios del Pino, Yvelise
A1 Yebra, Miguel
A1 Rincón, José
A1 Sanjuan, Isabel
A1 Díaz-Espada, Fernando
K1 Intravenous immunoglobulins,
K1 Cryoglobulins
AB Intravenous infusion of gammaglobulins (IVIG) is one of the treatments of choice in patients with type II mixed cryoglobulinemia (MC). We describe the case of a patient with MC who suffered an adverse generalised reaction with severe cutaneous vasculitis accompanied by a sudden increase in cryocrit levels shortly after being treated with IVIG. When the same gammaglobulin preparation was added in vitro to a sample of the patient's serum, a strong increment in cryoglobulin precipitation and depletion of the monoclonal IgM peak resulted. We suggest that this simple method of studying the displacement of the precipitation reaction could help to predict the outcome of treatment and must be performed before starting IVIG in patients with MC.
SN 0392-856X
YR 2002
FD 2002
LK http://riull.ull.es/xmlui/handle/915/34887
UL http://riull.ull.es/xmlui/handle/915/34887
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 10-may-2024