RT info:eu-repo/semantics/article
T1 Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow's milk allergy
A1 Barrios del Pino, Yvelise
A1 Poza‑Guedes, Paloma
A1 González‑Pérez, Ruperto
A1 Sánchez‑Machín, Inmaculada
A1 Franco, Andrés
A1 Matheu,  Víctor
K1 Cow’s milk allergy
K1 Food allergy
K1 Gastrointestinal allergy
K1 Specific IgE
K1 β‑lactoglobulin
K1 Casein
K1 Anaphylaxis
K1 IgE‑mediated allergy
AB Rationale: The prevalence of many phenotypes of food allergy is increasing. Specific gastrointestinal (GI) phenotype of food allergy (GI allergy) is also increasing but it is difficult to know the prevalence because of many entities. Methods and Results: A 1 year retrospective study of pediatric patients complaining exclusively gastrointestinal symptoms after cow's milk consumption and at least one positive specific IgE (sIgE) to cow's milk (CM) proteins (CMP) was done (n = 39). The most prevalent symptom was abdominal cramps in 35 patients (90 %), discomfort or abdominal distention in 30 patients (75 %), diarrhea in 10 patients (25 %) and constipation in 5 patients (12 %). IgA anti-transglutaminase antibodies were absent and lactose intolerance was ruled out in all patients. Average of total IgE on this group was 288 UI/ml. sIgE against β-lactoglobulin was the dominant with an average of 4.14 kU/l. sIgE to casein (CAS), which is the dominant protein in systemic anaphylaxis was 1.74 kU/l; sIgE to α-lactoalbumin, the other whey protein, was 0.83 kU/l and sIgE levels to CM were 0.78 kU/l. The quotient sIgE CAS/sIgE β-lactoglobulin in these patients was always lower than 1. Patients experienced an improvement of their symptoms after a CM free diet. An open oral challenge with CM did mimic their initial symptoms in all patients. However, the open oral challenge with dairy products was well tolerated. Conclusions: Patients with a specific phenotype of GI allergy with CM have specific IgE against β-lactoglobulin, as a dominant sIgE. These patients could beneficiate of a diet with dairy products.
SN 1710-1492,
YR 2016
FD 2016
LK http://riull.ull.es/xmlui/handle/915/34892
UL http://riull.ull.es/xmlui/handle/915/34892
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 12-sep-2024