RT info:eu-repo/semantics/article
T1 Infusion of lymphocytes obtained from a donor immunised with the paraprotein idiotype as a treatment in a relapsed myeloma
A1 Barrios del Pino, Yvelise
A1 Cabrera, Rafael
A1 Díaz-Espada, Fernando
A1 Briz, M.
A1 Forés, R.
A1 Barbolla, L.
A1 Sanjuán, I.
A1 Regidor, C.
A1 Penalver, F. J.
A1 Fernández, M. N.
K1 Multiple myeloma
K1 Idiotype vaccination
K1 Donor lymphocyte infusions
AB A 48-year-old patient with IgA k multiple myeloma received a BMT from his HLA-matched sibling. After transplantation, the disease relapsed. Melphalan therapy followed by reinfusion of haemopoietic blood stem cells collected from the patient led to the improvement of the clinical status, although mixed chimerism and an elevated serum IgA persisted. Successful donor immunisation against an immunogenic preparation of the recipient monoclonal protein was performed before the infusion of donor T lymphocytes (DLI) into the patient. Ten weeks after the lymphocyte infusions, no monoclonal band was evidenced and donor complete chimerism was detected. The patient did not develop GVHD. Once complete remission was achieved, the idiotype vaccine was administered to the patient. Nineteen months after DLI, the patient remains in remission.
SN 0268-3369
YR 2000
FD 2000
LK http://riull.ull.es/xmlui/handle/915/34894
UL http://riull.ull.es/xmlui/handle/915/34894
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 14-ene-2025