RT info:eu-repo/semantics/article
T1 Anti-idiotypic Immunotherapy in Follicular Lymphoma Patients
A1 Barrios del Pino, Yvelise
A1 Yáñez, Rosa
A1 Ruiz, Elena
A1 Cabrera, Rafael
A1 Dı´az-Espada, Fernando
K1 Lymphoma immunotherapy
K1 Idiotypic vaccination
K1 Tumor vaccines
AB A specific immune response against the individual idiotypic determinants of clonal immunoglobulins can be elicited in patients with B-cell malignancies. We analyze the clinical outcome and the presence of tumor cells in the blood of 8 patients with follicular lymphoma, vaccinated with autologous idiotype protein from their lymphoma cells. After a median follow-up of 90 months (range: 54 to 128), all patients, except 1, remain in complete clinical remission and 5 are in complete molecular remission. Our results suggest that idiotype vaccination induces long-lasting clinical and molecular remissions and constitutes a potential curative treatment in follicular lymphoma patients. © 2008 Lippincott Williams & Wilkins, Inc.
SN 1524-9557
YR 2008
FD 2008
LK http://riull.ull.es/xmlui/handle/915/34903
UL http://riull.ull.es/xmlui/handle/915/34903
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 01-jul-2024