RT info:eu-repo/semantics/article
T1 Autoantibody activity of the immunoglobulin secreted by a follicular B-cell lymphoma
A1 Barrios del Pino, Yvelise
A1 Plaza, A.
A1 Cabrera, R.
A1 Díaz Espada, F.
K1 Biclonal lymphoma
K1 Autoantibodies
K1 VH-genes
AB In patients with B-cell lymphoma, only in rare cases a secreted paraprotein is found, and in very few of them an associated autoantibody activity has been demonstrated. Here we report the case of apatient with a low-grade B-cell lymphoma with a serum biclonal paraprotein (G,M)l and severeerythroblastopenia. Indirect  immunofluorescence studies of total serum revealed cytoplasmic (Hep-2cells) and extracellular matrix (rat tissue sections) staining, suggestive of a new specificity. After gel filtration of serum samples, only the IgM-containing fraction showed the same pattern of staining.Tumor-derived hybridomas expressed an unmutated V3–11 gene identical to that found in tumorsamples and secreted an IgM immunoglobulin endowed with the same reactivity, which confirms thetumoral origin of the tissue-reactive protein. The results suggest a link between the autoimmunecondition in this patient and the novel specificity displayed by the tumor-derived immunoglobulin.
SN 0903-4641
YR 2000
FD 2000
LK http://riull.ull.es/xmlui/handle/915/34905
UL http://riull.ull.es/xmlui/handle/915/34905
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 22-nov-2024