RT info:eu-repo/semantics/article
T1 Isolated Ro52 Antibodies as Immunological Marker of a Mild Phenotype of Undifferentiated Connective Tissue Diseases
A1 Barrios del Pino, Yvelise
A1 Alonso-Larruga, Ana
A1 Bustabad, Sagrario
A1 Navarro-Gonzálvez, José Antonio
A1 Rodríguez-Lozano, Beatriz
A1 Franco, Andrés
AB The term undifferentiated connective tissue disease (UCTD) is used to describe undiagnosed patients that do not fulfill classification criteria for definite connective tissue disease (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis). It is important to find serological markers as predictors of the evolution or severity of these diseases. The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies. Immunological and clinical records of 62 patients attending the hospital during 30 months were studied. Results showed a target population formed by mostly women, aged between 40 and 80 years at the moment of the study, with a registered age of onset between 40 and 60 years. Speckled pattern was the most frequent pattern found by indirect immunofluorescence. Given the obtained results and keeping in mind possible limitations because of sample size, isolated positive anti-Ro52 autoantibodies seem to lead to a benign effect in terms of evolution of the disease. As a future objective, the follow-up of these patients should be necessary to investigate new clinical symptoms, serological markers, or development of a definite connective tissue disease over time.
SN 1687-9279
YR 2017
FD 2017
LK http://riull.ull.es/xmlui/handle/915/34909
UL http://riull.ull.es/xmlui/handle/915/34909
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 18-nov-2024