RT info:eu-repo/semantics/article
T1 Does female with chromosome translocation have a normal response to controlled ovarian hyperstimulation?
A1 Rodríguez Díaz, Rubí Nieves
A1 Salma Kaddouri-Kaddouri
A1 Cintia Concepción-Lorenzo
A1 Stephany Hess-Medler
A1 Jonay González-Pérez
A1 Rebeca Vaca-Sánchez
A1 Delia R Báez-Quintana
A1 Raquel Blanes-Zamora
K1 Chromosomal translocation
K1 reciprocal
K1 Robertsonian
K1 controlled ovarian stimulation
AB Patients with chromosomal translocation have been reported to have high risk of reproductive failure, lower ovarian response, recurrent pregnancy loss and implantation failure. The literature is not conclusive, and our objective is to study if female balanced translocation (BT) does affect the controlled ovarian stimulation (COS). We carried out a retrospective analysis of 3249 karyotypes between 2008 and 2016, including 2276 females and 973 males. 12 women (0.5%) with BT were compared with 93 control normal karyotype group (CN) in both female and male partner. An equivalent control group (EQc) of 12 patients was additionally selected to be accurate with the BT statistical contrast. Cycle, oocyte and embryo outcomes were analysed. We concluded that female BT carriers have no diminished response to COS than infertile females with normal karyotype. This is an important information for counselling couples previous to COS and preimplantational genetic testing (PGT).
SN 2354-211X
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/34980
UL http://riull.ull.es/xmlui/handle/915/34980
LA 
DS Repositorio institucional de la Universidad de La Laguna
RD 19-may-2024