RT info:eu-repo/semantics/article
T1 Intussusceptive angiogenesis facilitated by microthrombosis has an important example in angiolipoma. An ultrastructural and immunohistochemical study.
A1 Díaz Flores Feo, Lucio
A1 Gutiérrez García, Ricardo
A1 García, María Pino
A1 González Gómez, Miriam
A1 Díaz-Flores Varela, Lucio
A1 Carrasco Juan, José Luís
A1 Madrid Cuevas, Juan Francisco
A1 Álvarez Argüelles, Hugo
K1 Angiogenesis
K1 Angiolipoma
K1 Microcirculation
K1 Endothelial cells
K1 Thrombi
K1 Intussusceptive angiogenesis
K1 Coagulation
K1 Pericytes
AB The microvasculature of angiolipomafrequently presents thrombi. Our objectives are to assesswhether intussusceptive angiogenesis (IA) participates invasculature formation in non-infiltrating angiolipomaand, if so, to explore how thrombi are involved in the IAprocess. For this purpose, we studied angiolipomaspecimens (n: 52), using immunohistochemistry, andconfocal and electron microscopy. The results showedthe presence of folds and pillars, hallmarks of IA,dividing the vessel lumen. Folds showed a cover formedby reoriented endothelial cells from the vessel wall, orfrom newly formed folds, and a core initially formed bythrombus fragments (clot components as transitionalcore), which was replaced by extracellular matrix andinvaginating pericytes establishing numerous peg-andsocket junctions with endothelial cells (mature core). Acondensed plasmatic electron-dense material surroundedand connected folds and pillars with each other and withthe vascular wall, which suggests a clot role in fold/pillararrangement. In conclusion, we contribute to IAparticipation in capillary network formation inangiolipoma and the immunohistochemical andultrastructural events by which microthrombosisfacilitates IA. Therefore, in addition to the histogenesisof angiolipoma, we provide an easily obtainablesubstrate for future studies on clot component action inIA, of clinical and therapeutic interest.
SN 1699-5848
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/34999
UL http://riull.ull.es/xmlui/handle/915/34999
LA en
NO Epub 2022 Jul 1. PMID: 35775452.
DS Repositorio institucional de la Universidad de La Laguna
RD 22-may-2024