RT info:eu-repo/semantics/article
T1 The heterogeneity of human Cajal-Retzius neurons.
A1 González‐Gómez, Miriam
A1 Meyer, Gundela
K1 Cell death; Cortex development; GABA; interneurons; Reelin
AB The definition of a Cajal-Retzius neuron (CRN) is still controversial, in part possibly due to species differences. We review the developmental history of CRN in human neocortex and focus on two main CRN family members, transient (t) and persisting (p) CRN. They share the expression of Reelin andTbr1, complemented by p73, calretinin, CXCR4 and NOS, but differ in their moment of appearance, fate and morphology. The distinctive feature of tCRN is the axon plexus in the lower third of the marginal zone, which innervates the apical dendritic tufts of pyramidal cells and may serve as a migration substrate and waiting compartment for interneurons descending from the subpial granular layer (SGL) into the cortical plate. Around midgestation, the SGL also gives rise to a transient interneuron type, the miniature neuron, that provides the GABAergic innervation of tCRN, which eventually, through diverse signaling pathways involving p73, contribute to the demise of tCRN and the breakdown of their plexus. The pCRN appear in the last trimester of gestation and may derive from committed CRN progenitors which migrate with the SGL from the periolfactory forebrain. They lack the horizontal CR plexus, and may be implicated in cortical folding, distribution of blood vessels, and plasticity of microcircuits in the molecular layer
SN 1084-9521
YR 2018
FD 2018
LK http://riull.ull.es/xmlui/handle/915/35000
UL http://riull.ull.es/xmlui/handle/915/35000
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 30-dic-2024