RT info:eu-repo/semantics/article
T1 Participation of intussusceptive angiogenesis in the morphogenesis of lobular capillary hemangioma
A1 González Gómez, Miriam
A1 Díaz Flores, Lucio
A1 Gutiérrez, Ricardo
A1 Pino García, M. A.
A1 Carrasco, José Luis
A1 Díaz Flores, Lucio Jr.
A1 Madrid, Juan F.
A1 Álvarez Argüelles, Hugo
K1 angiogenesis
AB In lobular capillary hemangioma (LCH), misnamed pyogenic granuloma, only sprouting angiogenesis(SA) has been considered. We assess the occurrence of intussusceptive angiogenesis (IA) in LCH andwhether IA determines the specifc and other focal patterns in the lesion. For this purpose, we studyspecimens of 120 cases of LCH, using semithin sections (in 10), immunohistochemistry, and confocalmicroscopy (in 20). In addition to SA, the results in LCH showed (1) intussusceptive phenomena,including pillars/folds and associated vessel loops, which encircled interstitial tissue structures (ITSs). (2)Two types of evolved loops depending on interendothelial contacts from opposite walls: (a) numerousinterendothelial contacts, alternating with capillary-sized lumens (main capillary pattern of thelesion) and (b) few interendothelial contacts, wide open lumens, and intravascular transport of pillars/folds, which were arranged linearly, forming septa (focal sinusoidal-like pattern) or were irregularlygrouped (focal intravascular papillary endothelial hyperplasia, IPEH-like pattern). In conclusion, wedemonstrate that IA participates in synergistic interaction with SA in LCH development and that theprevalence of specifc intussusceptive phenomena determines the predominant capillary pattern andassociated sinusoidal hemangioma-like and IPEH-like patterns in the lesion, which suggest a role of IAas conditioner of vessel tumour/pseudo-tumour morphology.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/35010
UL http://riull.ull.es/xmlui/handle/915/35010
LA en
NO Sci Rep. 2020 Mar 19;10(1):4987. doi: 10.1038/s41598-020-61921-3. PMID: 3219341.Autores: Díaz-Flores L, Gutiérrez R, González-Gómez M, García MAP, Carrasco JL, Díaz-Flores L Jr, Madrid JF, Álvarez-Argüelles H.
DS Repositorio institucional de la Universidad de La Laguna
RD 24-may-2024