RT info:eu-repo/semantics/article
T1 Presence/absence and specific location of resident CD34+ stromal tells/Telocytes condition stromal cell development in repair and tumors.
A1 Díaz Flores Feo, Lucio
A1 Gutiérrez García, Ricardo
A1 García, María Pino
A1 González Gómez, Miriam
A1 Díaz-Flores Varela, Lucio
A1 Álvarez Argüelles, Hugo
K1 Gallbladder
K1 Colon
K1 Tumor stroma
K1 CD34+ stromal cells/telocytes
AB CD34+ stromal cells/telocytes (CD34+SCs/TCs) can have a role as mesenchymalprecursor cells. Our objective is to assess whether the myofibroblastic stromal cellresponse in repair and in desmoplastic reactions in tumors depend on the presenceor absence of resident CD34+SCs/TCs in specific regions/layers of an organ and onthe location of their possible subpopulations. For this purpose, using conventional andimmunohistochemical procedures, we studied specimens of (a) acute cholecystitis, withearly repair phenomena (n: 6), (b) surgically resected segments of colon tattooed withIndia ink during previous endoscopic removal of malignant polyps, with macrophageinfiltration and stromal cell reaction (n: 8) and (c) infiltrative adenocarcinomas of colon,with desmoplastic reaction (n: 8). The results demonstrated (a) stromal myofibroblasticreaction during repair and tumor desmoplasia in most regions in which residentCD34+SCs/TCs are present, (b) absence of stromal myofibroblastic reaction duringrepair in the mucosa of both organs in which resident CD34+SCs/TCs are absentand (c) permanence of CD34+SCs/TCs as such, without myofibroblastic response, insmooth muscle fascicles, nerves, and Meissner and Auerbach plexuses, in which theCD34+SCs/TCs mainly undergo reactive phenomena. Therefore, the development ofactivated αSMA+ myofibroblasts in these conditions requires the presence of residentCD34+SCs/TCs and depends on their location. In conclusion, the facts support thehypotheses that CD34+SCs/TCs participate in the origin of myofibroblasts during repairand tumor stroma formation, and that there is a heterogeneous population of residentCD34+SCs/TCs with different roles.
SN 2296-634X
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/35011
UL http://riull.ull.es/xmlui/handle/915/35011
LA en
NO PMID: 33072740; PMCID: PMC7530324.
DS Repositorio institucional de la Universidad de La Laguna
RD 22-may-2024