RT info:eu-repo/semantics/article
T1 Glia fascicle leads principal neurons from the pallial-subpallial boundary into the developing human insula.
A1 González Gómez, Miriam
A1 González Arnay, Emilio
A1 Meyer, Gundela
A2 Ciencias Médicas Básicas
A2 Grupo de investigación: Neurobiología Humana.
K1 cytoarchitecture
K1 inner granular layer
K1 pallial-subpallial boundary
K1 lateral cortical stream
K1 migration
K1 radial glia
AB The human insular lobe, in the depth of the Sylvian fissure, displays three maincytoarchitectonic divisions defined by the differentiation of granular layers II and IV.These comprise a rostro-ventral agranular area, an intermediate dysgranular area, anda dorso-caudal granular area. Immunohistochemistry in human embryos and fetusesusing antibodies against PCNA, Vimentin, Nestin, Tbr1, and Tb2 reveals that the insularcortex is unique in that it develops far away from the ventricular zone (VZ), with most ofits principal neurons deriving from the subventricular zone (SVZ) of the pallial-subpallialboundary (PSB). In human embryos (Carnegie stage 16/17), the rostro-ventral insulais the first cortical region to develop; its Tbr1+ neurons migrate from the PSB alongthe lateral cortical stream. From 10 gestational weeks (GW) onward, lateral ventricle,ganglionic eminences, and PSB grow forming a C-shaped curvature. The SVZ of thePSB gives rise to a distinct radial glia fiber fascicle (RGF), which courses lateral to theputamen in the external capsule. In the RGF, four components can be established: PF,descending from the prefrontal PSB to the anterior insula; FP, descending from thefronto-parietal PSB toward the intermediate insula; PT, coursing from the PSB near theparieto-temporal junction to the posterior insula, and T, ascending from the temporalPSB and merging with components FP and PT. The RGF fans out at different dorsoventral and rostro-caudal levels of the insula, with descending fibers predominatingover ascending ones. The RGF guides migrating principal neurons toward the futureagranular, dysgranular, and granular insular areas, which show an adult-like definitionat 32 GW. Despite the narrow subplate, and the absence of an intermediate zoneexcept in the caudal insula, most insular subdivisions develop into a 6-layered isocortex,possibly due to the well developed outer SVZ at the PSB, which is particularly prominentat the level of the dorso-caudal insula. The small size of the initial PSB sector may,however, determine the limited surface expansion of the insula, which is in contrast tothe exuberant growth of the opercula deriving from the adjacent frontal-parietal andtemporal VZ/SVZ
YR 2017
FD 2017
LK http://riull.ull.es/xmlui/handle/915/35012
UL http://riull.ull.es/xmlui/handle/915/35012
LA en
NO A Radial  Front Neuroanat. 2017 Dec 5;11:111. doi: 10.3389/fnana.2017.00111. PMID: 29259547; PMCID: PMC5723317.Autores: González-Arnay E, González-Gómez M, Meyer G
DS Repositorio institucional de la Universidad de La Laguna
RD 30-may-2024