RT info:eu-repo/semantics/article
T1 Myriad pillars formed by intussusceptive angiogenesis as the basis of intravascular papillary endothelial hyperplasia (IPEH). IPEH is intussusceptive angiogenesis made a lesion.
A1 González Gómez, Miriam
A1 Lucio Díaz-Flores
A1 Gutiérrez, Ricardo
A1 García, Mª Pino
A1 Carrasco, José Luis
A1 Díaz Flores, Lucio Jr
A1 Madrid, Juan F.
A2 Ciencias Médicas Básicas
A2 Grupo de investigación: Neurobiología Humana.
K1 Intussusceptive angiogenesis
K1 Endothelial cells
K1 Vein wall vascularization
AB Intussusceptive angiogenesis (IA) is the  process by which pre-existing blood vessels split,  expand and remodel through intravascular pillar  formation. In previous works, we studied the  morphologic characteristics of intravascular papillary  endothelial hyperplasia (IPEH) and suggested the  participation of IA in the histogenesis of the lesion. Our  current goal is to demonstrate that myriad papillae inIPEH are in fact myriad pillars, the hallmarks of IA. For this purpose, specimens of 14 cases of IPEH were used for conventional histologic techniques, immunohistochemistry and immunofluorescence in confocal microscopy. The studies showed the following pillar characteristics: a) structural composition by an endothelial cell (EC) cover and a connective core, b)  characteristic pillar image and its appearance and  disappearance in whole-mounted and series of individual views in confocal microscopy (requirements for pillar  identification), c) arrangement in masses, alignments andmeshes, and d) formation from vein intimal ECs, which  extend and originate loops that encircle vein wall components (interstitial tissue structures: ITSs) and fibrin. The encircling ECs form the pillar cover and the  encircled ITSs or fibrin form the initial core.Intraluminal endothelial bridges also originate from the  vessel wall and from the pillars (nascent and thin  pillars). In conclusion, the formation of myriad pillars,  predominantly in veins, is the basis of IPEH. This lesion may therefore be considered an excessive expression of IA: IA becomes a lesion.
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/35013
UL http://riull.ull.es/xmlui/handle/915/35013
NO 
DS Repositorio institucional de la Universidad de La Laguna
RD 30-dic-2024