T1 The subpial granular layer and transient versus persisting Cajal-Retzius neurons of the fetal human cortex. A1 González Gómez, Miriam A1 Meyer, Gundela K1 Cell death K1 Cortex development K1 GABA K1 Interneurons AB Neurons of the subpial granular layer (SGL) in the human marginal zone (MZ) migrate tangentially from the periolfactorysubventricular zone all over the neocortex. After an immature stage, from 14 to 18 gestational weeks (GW), the SGL attainsmaximum prominence around midgestation. At 20–25 GW, a transient miniature cell type in the MZ expresses glutamatedecarboxylase (GAD) and calretinin, and extends a varicose plexus surrounding somata of large transient Cajal-Retziusneurons (tCRN), potentially modulating their activity. The compact Reelin+ horizontal axon plexus of tCRN forms atransient interface between cortical plate and MZ; it may serve as a migration substrate for cortical interneurons, andattracting NPY+ fibers from the subplate. Around 30 GW, after the disappearance of SGL and tCRN, a population of persistingCajal-Retzius neurons (pCRN) appears and remains into adult life. pCRNs express Reelin, Tbr1, calretinin, nitric oxidesynthase, and the cytokine receptor CXCR4. They are characterized by subpial location, closeness to blood vessels, andaggregation in the walls of developing sulci. Unlike tCRNs, pCRNs do not develop a compact axon plexus in the lower MZ.Occasional mitoses in the midgestation SGL suggest that CRN progenitor cells may give rise to late-appearing pCRNspopulating the definitive molecular layer. YR 2017 FD 2017 LK http://riull.ull.es/xmlui/handle/915/35019 UL http://riull.ull.es/xmlui/handle/915/35019 LA en DS Repositorio institucional de la Universidad de La Laguna RD 23-jun-2024