RT info:eu-repo/semantics/article
T1 NTS, NTSR1 and ERs in the pituitary-gonadal axis of cycling and postnatal female rats after BPA treatment.
A1 González Gómez, Miriam
A1 Reyes, Ricardo
A1 Damas Hernández, Mª del Carmen
A1 Plasencia Cruz, Xiomara
A1 González Marrero, Ibrahim
A1 Alonso, Rafael
A1 Bello, Aixa R.
K1 Neurotensin; Neurotensin receptor; Estrogen receptors; Bisphenol-A; Pituitary gland; Ovaries
AB The neuropeptide neurotensin (NTS) is involved in regulating the reproductive axis and is expressed at each level of this axis (hypothalamus–pituitary–gonads). This dependence on estrogen levels has been widely demonstrated in the hypothalamus and pituitary. We focused on confirming the relationship of NTS with estrogens and the gonadal axis, using a particularly important environmental estrogenic molecule, bisphenol-A (BPA). Based on the experimental models or in vitro cell studies, it has been shown that BPA can negatively affect reproductive function. We studied for the first time the action of an exogenous estrogenic substance on the expression of NTS and estrogen receptors in the pituitary-gonadal axis during prolonged in vivo exposure. The exposure to BPA at 0.5 and 2 mg/kg body weight per day during gestation and lactation was monitored through indirect  immunohistochemical procedures applied to the pituitary and ovary sections. Our results demonstrate that BPA induces alterations in the reproductive axis of the offspring, mainly after the first postnatal week. The rat pups exposed to BPA exhibited accelerated sexual maturation to puberty. There was no effect on the number of rats born per litter, although the fewer primordial follicles suggest a shorter fertile life.
SN 1422-0067
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/35020
UL http://riull.ull.es/xmlui/handle/915/35020
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 19-nov-2024