RT info:eu-repo/semantics/article
T1 CD34+ Stromal Cells/Telocytes as a Source of Cancer-Associated Fibroblasts (CAFs) in Invasive Lobular Carcinoma of the Breast.
A1 González Gómez, Miriam
A1 Díaz‐flores, Lucio
A1 Gutiérrez, Ricardo
A1 García, María Pino
A1 Carrasco, José Luís
A1 Martín‐Vasallo, Pablo
A2 Ciencias Médicas Básicas
A2 Grupo de investigación: Neurobiología Humana.
K1 Telocytes
K1 Cancer-associated fibroblasts
K1 CAFs
K1 Invasive lobular carcinoma
K1 Breast
AB Several origins have been proposed for cancer‐associated fibroblasts (CAFs), including resident CD34+ stromal cells/telocytes (CD34+SCs/TCs). The characteristics and arrangement of mammary CD34+SCs/TCs are well known and invasive lobular carcinoma of the breast (ILC) is one of the few malignant epithelial tumours with stromal cells that can express CD34 or αSMA, which could facilitate tracking these cells. Our objective is to assess whether tissue‐resident CD34+SCs/TCs participate in the origin of CAFs in ILCs. For this purpose, using conventional and immunohisto-chemical procedures, we studied stromal cells in ILCs (n:42) and in normal breasts (n:6, also using electron microscopy). The results showed (a) the presence of anti‐CD34+ or anti‐αSMA+ stromal cells in varying proportion (from very rare in one of the markers to balanced) around nests/strands of neoplastic cells, (b) a similar arrangement and location of stromal cells in ILC to CD34+SCs/TCs in the normal breast, (c) both types of stromal cells coinciding around the same nest of neoplastic cells and (d) the coexpression of CD34 and αSMA in stromal cells in ILC. In conclusion, our findings support the hypothesis that resident CD34+SCs/TCs participate as an important source of CAFs in ILC. Further studies are required in this regard in other tumours.
SN 1422-0067
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/35025
UL http://riull.ull.es/xmlui/handle/915/35025
LA en
NO Int J Mol Sci. 2021 Apr 1;22(7):3686. doi: 10.3390/ijms22073686. PMID: 33916213; PMCID: PMC8037555.Autores: Díaz-Flores L, Gutiérrez R, González-Gómez M, García MP, Díaz-Flores L Jr, Carrasco JL, Martín-Vasallo P.
DS Repositorio institucional de la Universidad de La Laguna
RD 27-nov-2024