RT info:eu-repo/semantics/article T1 Intussusceptive angiogenesis and peg-socket junctions between endothelial cells and smooth muscle cells in early arterial intimal thickening A1 González Gómez, Miriam A1 Díaz Flores , Lucio A1 Gutiérrez, Ricardo A1 García, Mª Pino A1 Gayoso, Sara A1 Carrasco, José Luis A1 Díaz Flores, Lucio Jr. A1 González Gómez, Miriam A1 Madrid, Juan Francisco K1 Arterial intimal thickening K1 Angiogenesis K1 Intussusceptive angiogenesis K1 Peg-and-socket junctions K1 Vascular regression K1 Endothelial cells K1 Vascular smooth muscle cells K1 Platelets AB Angiogenesis in arterial intimal thickening (AIT) has been considered mainly in late AIT stages and only refers to sprouting angiogenesis. We assess angiogenesis during early AIT development and the occurrence of the intussusceptive type. For this purpose, we studied AIT development in (a) human arteries with vasculitis in gallbladders with acute cholecystitis and urgent (n = 25) or delayed (n = 20) cholecystectomy, using immunohistochemical techniques and (b) experimentally occluded arterial segments (n = 56), using semithin and ultrathin sections and electron microscopy. The results showed transitory angiogenic phenomena, with formation of an important microvasculature, followed by vessel regression. In addition to the sequential description of angiogenic and regressive findings, we mainly contribute (a) formation of intravascular pillars (hallmarks of intussusception) during angiogenesis and vessel regression and (b) morphological interrelation between endothelial cells (ECs) in the arterial wall and vascular smooth muscle cells (VSMCs), which adopt a pericytic arrangement and establish peg-and-socket junctions with ECs. In conclusion, angiogenesis and vessel regression play an important role in AIT development in the conditions studied, with participation of intussusceptive angiogenesis during the formation and regression of a provisional microvasculature and with morphologic interrelation between ECs and VSMCs. YR 2020 FD 2020 LK http://riull.ull.es/xmlui/handle/915/35027 UL http://riull.ull.es/xmlui/handle/915/35027 LA NO Int J Mol Sci. 2020 Oct 28;21(21):8049. doi: 10.3390/ijms21218049. PMID: 33126763; PMCID: PMC7663623.Autores: Díaz-Flores L, Gutiérrez R, García MP, Gayoso S, Carrasco JL, Díaz-Flores L Jr, González-Gómez M, Madrid JF. DS Repositorio institucional de la Universidad de La Laguna RD 05-dic-2024