RT info:eu-repo/semantics/article T1 Intussusceptive lymphangiogenesis in vascular transformation of lymph node sinuses. A1 González Gómez, Miriam A1 Gutiérrez, Ricardo A1 García, María del Pino A1 Díaz-Flores, Lucio . A1 Carrasco, José Luis A1 Álvarez-Argüelles, Hugo K1 Angiogenesis K1 Intussusceptive lymphangiogenesis K1 Lymph node AB Numerous lymphatic anastomosing channels in the lymph nodes are the most demonstrative finding of the rare lesion termed “vascular transformation of lymph node sinuses” (VTS). The mechanism of lymphatic vessel formation in VTS has not been studied. Vessel intussusception contributes to vascular expansion, and intraluminal pillars/posts, interstitial tissue structures or larger pillars (ITSs) and folds are the hallmarks of this process in blood vessels. The aim of this work is to assess whether these hallmarks of intussusception occur inVTS lymphatic vessels, indicating intussusceptive lymphangiogenesis. For this purpose, specimens of five cases of VTS were used for serial histological sections, immunohistochemistry and immunofluorescence in confocal microscopy, which enabled us to demonstrate the 3D image that defines the pillars. The studies showed a) meshworks of lymphatic vessels, which form complex loops, resembling sinuses of lymph nodes, b) presence ofintralymphatic pillars, ITSs and folds, with a cover of lymphatic endothelial cells expressing podoplanin and a varying-sized connective core (e.g. collagen), and c) increase of vessel meshwork and linear arrangement, splitting and fusion of ITSs, pillars and folds, with remodelling and segmentation. In conclusion, the development of lymphatic vessel loops, ITSs, pillars and folds with segmentation in VTS supports intussusceptive lymphangiogenesis. This mechanism of intussusception is of interest because it participates in VTS histogenesis,contributes to general knowledge of intussusceptive lymphangiogenesis, which has received less attention than intussusception in blood vessels, and provides a basis for further studies in other lymphatic conditions SN 0065-1281 YR 2019 FD 2019 LK http://riull.ull.es/xmlui/handle/915/35028 UL http://riull.ull.es/xmlui/handle/915/35028 LA en NO Acta Histochem. 2019 May;121(4):392-399. doi: 10.1016/j.acthis.2019.03.001. Epub 2019 Mar 6. PMID: 30850131.Autores: Díaz-Flores L, Gutiérrez R, García MP, González-Gómez M, Díaz-Flores L Jr, Carrasco JL, Álvarez-Argüelles H. DS Repositorio institucional de la Universidad de La Laguna RD 12-nov-2024