RT info:eu-repo/semantics/article
T1 Telocytes/CD34+ Stromal Cells in the Normal, Hyperplastic, and Adenomatous Human Parathyroid Glands.
A1 González Gómez, Miriam
A1 Díaz-Flores Varela, Lucio
A1 Gutiérrez García, Ricardo
A1 García, María del Pino
A1 Carrasco Juan, José Luis
A1 Madrid, Juan Francisco
A1 Díaz-Flores Varela, Lucio
K1 telocytes
K1 CD34+ stromal cells
K1 parathyroid glands
K1 hyperplasia of parathyroids
K1 parathyroid adenoma
K1 adipose tissue
AB Telocytes/CD34+ stromal cells (TCs/CD34+ SCs) have been studied in numerous organsand tissues, but their presence and characteristics in the parathyroid glands have not been explored.Using immunological and ultrastructural procedures, we assess the location, arrangement, andbehavior of TCs/CD34+ SCs in normal human parathyroids, during their development and in theirmost frequent pathologic conditions. In normal parathyroids, TCs/CD34+ SCs show a small somaticbody and long thin processes with a moniliform aspect, form labyrinthine systems, connect otherneighboring TCs/CD34+ SCs, vessels, adipocytes, and parenchymal cells directly or by extracellularvesicles, and associate with collagen I. TCs/CD34+ SCs and collagen I are absent around vessels andadipocytes within parenchymal clusters. In developing parathyroids, TCs/CD34+ SC surround smallparenchymal nests and adipocytes. In hyperplastic parathyroids, TCs/CD34+ SCs are prominentin some thickened internodular septa and surround small extraglandular parenchymal cell nests.TCs/CD34+ SCs are present in delimiting regions with compressed parathyroids and their capsule inadenomas but absent in most adenomatous tissue. In conclusion, TCs/CD34+ SCs are an importantcellular component in the human parathyroid stroma, except around vessels within parenchymalnests. They show typical characteristics, including those of connecting cells, are present in developingparathyroids, and participate in the most frequent parathyroid pathology, including hyperplastic andadenomatous parathyroids.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/35029
UL http://riull.ull.es/xmlui/handle/915/35029
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 21-may-2024