RT info:eu-repo/semantics/article
T1 Telocytes/CD34+ Stromal Cells in Pathologically Affected White Adipose Tissue.
A1 González Gómez, Miriam
A1 Díaz-Flores, Lucio
A1 Gutiérrez, Ricardo
A1 García, Mª Pino
A1 Carrasco, Jose Luís
A1 Alvarez-Argüelles, Hugo
A1 Díaz-Flores Jr., Lucio
K1 telocytes
K1 CD34+ stromal cells
K1 adipose tissue
K1 repair
K1 tumour stroma
K1 adipose tissue
tumours
K1 amyloidosis
K1 irradiation
AB We studied telocytes/CD34+ stromal cells (TCs/CD34+SCs) in pathologically affected whiteadipose tissue after briefly examining them in normal fat. To this aim, we reviewed pathologicalprocesses, including original contributions, in which TCs/CD34+SCs are conserved, increased, and lost,or acquire a specific arrangement. The pathologic processes in which TCs/CD34+SCs are studied inadipose tissue include inflammation and repair through granulation tissue, iatrogenic insulin-amyloidtype amyloidosis, non-adipose tissue components (nerve fascicles and fibres in neuromas andhyperplastic neurogenic processes) and tumours (signet ring carcinoma with Krukenberg tumourand colon carcinoma) growing in adipose tissue, adipose tissue tumours (spindle cell lipoma,dendritic fibromyxolipoma, pleomorphic lipoma, infiltrating angiolipoma of skeletal muscle andelastofibrolipoma), lipomatous hypertrophy of the interatrial septum, nevus lipomatosus cutaneoussuperficialis of Hoffman–Zurhelle and irradiated adipose tissue of the perirectal and thymic regions.Two highly interesting issues emerged: (1) whether the loss of CD34 expression in TCs/CD34+SCs isby changes in marker expression or the disappearance of these cells (the findings suggest the firstpossibility) and (2) whether in some invasive and metastatic malignant tumours, TCs/CD34+SCs thatcompletely surround neoplastic cells act as nurse and/or isolating cells. Further studies are requiredon adipose tissue TCs/CD34+SCs, mainly in lipomatosis and obesity.
SN 1422-0067
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/35030
UL http://riull.ull.es/xmlui/handle/915/35030
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 21-dic-2024