RT info:eu-repo/semantics/article
T1 HLA-G and endometrial receptivity.
A1 Rodríguez Díaz, Rubí Nieves
K1 Endometriosis
K1 Fertilidad
AB The endometrium is a complex and dynamic tissue, which experiences physiological and cyclical changes each month, in response toovarian hormones, cytokines and chemokines [1-3]. The embryo iscapable of attach to the uterine endometrium during a short and selflimited period, in which the endometrial tissue acquires a functionalcondition that allows the interaction trophoblast-endometrium andtherefore, it is receptive. The embryo enters the uterine cavity as anunhatched blastocyst and undergoes its final development throughhatching to attachment to the uterine luminal epithelium within theenvironment of uterine fluid. The embryo first enters the uterine cavity as blastocyst and attached to the uterine epithelium [4] (Figure1). Decidualization of endometrial stromal cells is mainly induced byovarian steroids and progesterone-dependent decidualization is mediated in part by the second messenger cAMP [5], decidualization istaking place with the secretory transformation of the uterine glands,particularly of specialized uterine natural killer cells and vascular remodelling [6].Endometrial receptivity (ER) is defined as a temporary uniquefactors sequence that make the endometrium receptive to the embryonic implantation [7]. This specific period is regulated by a combination of ovarian steroids hormones and genetic factors and is knownas “window of implantation” (WOI). It takes place between 6 and 10days after ovulation [8], and it remains receptive during a short periodof time, about the 20-24th of a cycle of 28 days [9]. During this periodthe endometrium undergoes morphological, cytoskeletal, biochemical, and genetic changes to become functionally competent [10].Embryo implantation is a process comprising several cellular,ultrastructural and molecular mechanisms initiated and mediated bythe endometrium, the embryo and the interaction of both. In orderthat the embryonic implantation takes place, there is indispensablethe concurrence of three fundamental elements: embryo quality, endometrial receptivity in WOI and embryo-endometrial interaction[11-13]. Figure.2 but timing endometrial receptivity is still a challenge. These processes are controlled by different factors, includingovarian steroids and its receptors, cytokines, growth factors, adhesionmolecules, transcriptional factors and many others [14].The detection of WOI in every patient, in a personalized way,would be essential and would allow to increase pregnancy rates inART. Failure of the endometrium to achieve receptivity and the timing of the receptive period are now recognised as important issues inthe success of IVF [4].
YR 2018
FD 2018
LK http://riull.ull.es/xmlui/handle/915/35215
UL http://riull.ull.es/xmlui/handle/915/35215
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 19-nov-2024