RT info:eu-repo/semantics/article
T1 Contribution of the HIV-1 Envelope Glycoprotein to AIDS Pathogenesis and Clinical Progression.
A1 Valenzuela Fernández, Agustín
A1 Cabrera Rodríguez, Romina
A1 Casado, Concha
A1 Pérez-Yanes, Silvia
A1 Pernas, María
A1 García Luis, Jonay
A1 Marfil, Silvia
A1 Olivares, Isabel
A1 Estévez Herrera, Judith
A1 Trujillo González, Rodrigo Francisco
A1 Blanco, Julià
A1 López Galíndez, Cecilio
A2 Medicina Física y Farmacología
A2 Grupo "Inmunología Celular y Viral".
K1 HIV-1 Env function
K1 natural control of the infection
K1 elite controllers
AB In the absence of antiviral therapy, HIV-1 infection progresses to a wide spectrum of clinicalmanifestations that are the result of an entangled contribution of host, immune and viral factors. Thecontribution of these factors is not completely established. Several investigations have described theinvolvement of the immune system in the viral control. In addition, distinct HLA-B alleles, HLA-B27,-B57-58, were associated with infection control. The combination of these elements and antiviral hostrestriction factors results in different clinical outcomes. The role of the viral proteins in HIV-1 infectionhas been, however, less investigated. We will review contributions dedicated to the pathogenesisof HIV-1 infection focusing on studies identifying the function of the viral envelope glycoprotein(Env) in the clinical progression because of its essential role in the initial events of the virus life-cycle.Some analysis showed that inefficient viral Envs were dominant in non-progressor individuals. Thesepoorly-functional viral proteins resulted in lower cellular activation, viral replication and minor viralloads. This limited viral antigenic production allows a better immune response and a lower immuneexhaustion. Thus, the properties of HIV-1 Env are significant in the clinical outcome of the HIV-1infection and AIDS pathogenesis.
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/35326
UL http://riull.ull.es/xmlui/handle/915/35326
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 21-nov-2024