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T1 Longitudinal study of a SARS-CoV-2 infection in an immunocompromised patient with X-linked agammaglobulinemia.
A1 Valenzuela Fernández, Agustín
A1 Ciuffreda, Laura
A1 Lorenzo Salazar, José M.
A1 Alcoba Florez, Julia
A1 Rodriguez Pérez, Héctor
A1 Gil Campesino, Helena
A1 Hayek Peraza, Marcelino
A1 Rojo Alba, Susana
A1 Álvarez Argüelles, Marta Elena
A1 Díez Gil, Óscar
A1 González Montelongo, Rafaela
A1 Flores, Carlos
A2 Medicina Física y Farmacología
A2 Grupo "inmunología Celular y Viral".
K1 Immunocompromised patient
K1 long-term viral shedding
K1 SARS-CoV-2
K1 COVID-19
K1 viral variants
AB We describe the case of a 23-year-old immunocompromised male patient with clinically diagnosed Xlinked agammaglobulinemia who was admitted to the hospital on the 14th April 2020 due to coronavirusdisease of 2019 (COVID-19). Despite COVID-19 test negativizations, the patient was hospitalized most ofthe time and finally admitted to the intensive care unit where he died from multiorgan failure and shock.Over 149 days, 26 respiratory samples were collected, subjected to viral genome sequencing, and allassigned to the same lineage, supporting a single viral infection event. The accumulation of mutationsthroughout the course of the infection was accelerated and suggested the presence ofcompartmentalized viral subpopulations that evolved independently in the upper and lower respiratoryairways. These results support that long-term viral shedding in immunocompromised patients is onepossible mechanism for the emergence of variants of concern and provide evidence towards the infectioncontrol guidelines in these patients.
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/35336
UL http://riull.ull.es/xmlui/handle/915/35336
LA en
NO Preprint Research Square.DOI: https://doi.org/10.21203/rs.3.rs-702594/v2License: ¿ ¿ This work is licensed under a Creative Commons Attribution 4.0 International License.
DS Repositorio institucional de la Universidad de La Laguna
RD 16-jun-2024