RT info:eu-repo/semantics/article
T1 HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions
A1 Valenzuela Fernández, Agustín
A1 Cabrero, J. Román
A1 Serrador, Juan M.
A1 Sáchez Madrid, Francisco
A2 Medicina Física y Farmacología
AB Histone deacetylase 6 (HDAC6) is a cytoplasmic enzymethat regulates many important biological processes,including cell migration, immune synapse formation,viral infection, and the degradation of misfoldedproteins. HDAC6 deacetylates tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins.Although HDAC6 enzymatic activity seems to berequired for the regulation of cell morphology, the roleof HDAC6 in lymphocyte chemotaxis is independent ofits tubulin deacetylase activity. The diverse functions ofHDAC6 suggest that it is a potential therapeutic targetfor the treatment of a range of diseases. This reviewexamines the biological actions of HDAC6, focusing onits deacetylase activity and its potential scaffold functions in the regulation of cell migration and other keybiological processes in which the cytoskeleton plays animportant role.
YR 2008
FD 2008
LK http://riull.ull.es/xmlui/handle/915/35345
UL http://riull.ull.es/xmlui/handle/915/35345
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 19-may-2024