RT info:eu-repo/semantics/article
T1 Synthesis and antiproliferative activity of new 2-glyco-3-nitro-2H-chromenes
A1 Padrón Carrillo, José Manuel
A1 Luque Agudo, Verónica
A1 Albarrán Velo,  Jesús
A1 Light, Mark. E.
A1 Román, Emilio
A1 Serrano, José A.
A1 Gil, Victoria
A2 Química Orgánica
A2 BioLabInstituto Universitario de Bio-Orgánica Antonio González
K1 3‐nitro‐2H‐chromenes
K1 antiproliferative activity
K1 structure‐activity relationship
K1 carbohydrates
AB 3‐nitro‐2H‐chromenes and derivatives are compounds with diverse biological activity, among them, new 2‐glyco‐3‐nitro‐2H‐chromenes have been prepared by one‐pot oxa‐Michael‐Henry‐dehydration  reactions  between  carbohydrate‐derived  nitroalkenes  and  several salicylaldehydes, using a minimal amount of solvent and DBU as catalyst. The antiproliferative activity of these new compounds has been evaluated against a panel of six human solid tumor cell lines, and compared to pharmacological reference compounds, finding that their activities are in the low micromolar range and that some of them are more effective than the standards.
SN 0045-2068
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/35361
UL http://riull.ull.es/xmlui/handle/915/35361
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 09-ago-2024