RT info:eu-repo/semantics/article
T1 HIV Infection: Shaping the Complex, Dynamic, and Interconnected Network of the Cytoskeleton.
A1 Valenzuela Fernández, Agustín
A1 Cabrera Rodríguez, Romina
A1 Pérez Yanes, Silvia
A1 Lorenzo Sánchez, Iria
A1 Trujillo González, Rodrigo Francisco
A1 Estévez Herrera, Judith
A1 García Luis, Jonay
A2 Medicina Física y Farmacología
A2 Grupo "Inmunología Celular y Viral"
K1 HIV-1 infection
K1 HIV-1 Env complex
K1 HIV-1 Pr55Gag
K1 cytoskeleton dynamics
K1 cytoskeleton adaptors and motor proteins
K1 control of the infection
K1 viremia and progression
AB HIV-1 has evolved a plethora of strategies to overcome the cytoskeletal barrier (i.e., actinand intermediate filaments (AFs and IFs) and microtubules (MTs)) to achieve the viral cycle. HIV-1modifies cytoskeletal organization and dynamics by acting on associated adaptors and molecularmotors to productively fuse, enter, and infect cells and then traffic to the cell surface, where virionsassemble and are released to spread infection. The HIV-1 envelope (Env) initiates the cycle by bindingto and signaling through its main cell surface receptors (CD4/CCR5/CXCR4) to shape the cytoskeleton for fusion pore formation, which permits viral core entry. Then, the HIV-1 capsid is transportedto the nucleus associated with cytoskeleton tracks under the control of specific adaptors/molecularmotors, as well as HIV-1 accessory proteins. Furthermore, HIV-1 drives the late stages of the viralcycle by regulating cytoskeleton dynamics to assure viral Pr55Gag expression and transport to the cellsurface, where it assembles and buds to mature infectious virions. In this review, we therefore analyzehow HIV-1 generates a cell-permissive state to infection by regulating the cytoskeleton and associatedfactors. Likewise, we discuss the relevance of this knowledge to understand HIV-1 infection andpathogenesis in patients and to develop therapeutic strategies to battle HIV-1.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/35362
UL http://riull.ull.es/xmlui/handle/915/35362
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 29-may-2024