RT info:eu-repo/semantics/article
T1 Specific pattern of linguistic impairment in Parkinson's disease patients with subjective cognitive decline and mild cognitive impairment predicts dementia
A1 Galtier Hernández, Iván
A1 Nieto Barco, Antonieta
A1 Mata González, María
A1 Lorenzo,  Jesús N.
A1 Barroso Ribal, José Domingo
K1 Movement disorders
K1 Follow-up study
K1 Dual syndrome hypothesis
K1 Language disorders
K1 Sentence comprehension
AB Parkinson’s disease patients with subjective cognitive decline (PD-SCD) and mild cognitive impairment (PD-MCI) have an increased risk of dementia (PDD). Thus, the identification of early cognitive changes that can be useful predictors of PDD is a highly relevant challenge. Posterior cortically based functions, including linguistic processes, have been associated with PDD. However, investigations that have focused on linguistic functions in PD-MCI are scarce and none of them include PD-SCD patients. Our aim was to study language performance in PD-SCD and PD-MCI. Moreover, language subcomponents were considered as predictors of PDD.Method:Forty-six PD patients and twenty controls were evaluated with a neuropsychological protocol. Patients were classified as PD-SCD and PD-MCI. Language production and comprehension was assessed. Follow-up assessment was conducted to a mean of 7.5 years after the baseline.Results:PD-MCI patients showed a poor performance in naming (actions and nouns), action generation, anaphora resolution and sentence comprehension (with and without center-embedded relative clause). PD-SCD showed a poor performance in action naming and action generation. Deficit in action naming was an independent risk factor for PDD during the follow-up. Moreover, the combination of deficit in action words and sentence comprehension without a center-embedded relative clause was associated with a greater risk.Conclusions:The results are of relevance because they suggest that a specific pattern of linguistic dysfunctions, that can be present even in the early stages of the disease, can predict future dementia, reinforcing the importance of advancing in the knowledge of linguistic dysfunctions in predementia stages of PD.
SN 1469-7661
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/35388
UL http://riull.ull.es/xmlui/handle/915/35388
LA en
NO https://doi:10.1017/S1355617722000571
DS Repositorio institucional de la Universidad de La Laguna
RD 02-ene-2025