RT info:eu-repo/semantics/article
T1 Subjective cognitive decline and progression to dementia in Parkinson's disease: a long-term follow-up study
A1 Galtier Hernández, Iván
A1 Nieto Barco, Antonieta
A1 Lorenzo, Jesús N.
A1 Barroso Ribal, José Domingo
A2 Psicología ClínicaPsicobiología y Metodología
A2 Grupo de investigación ULL: Neuropsicología
Facultad de Psicología y Logopedia
Instituto Universitario de Neurociencia
K1 Mild cognitive impairment
K1 Dementia
K1 Neuropsychological assessment
K1 Memory
K1 Follow-up study
K1 Risk factor
AB Introduction Increasing evidence suggests that subjective cognitive decline is associated with Alzheimer’s disease pathology and with an increased risk for future dementia development. However, the clinical value of subjective cognitive declinein Parkinson’s disease (PD-SCD) is unclear. The aim of the present work was to characterize PD-SCD and its progressionto dementia.Methods Forty-three PD patients and twenty normal controls were evaluated with a neuropsychological protocol. Patientswere classified as PD-SCD and PD with mild cognitive impairment (PD-MCI). Follow-up assessment was conducted to amean of 7.5 years after the baseline.Results Thirteen patients were diagnosed with PD-SCD (30.2%) and 22 patients were classified as PD-MCI (51.2%) at thebaseline. Difficulties in language (60.5%) and memory (51.5%) were the most frequent cognitive complaints. PD-MCI showedalterations in processing speed, executive functions, visuospatial skills, memory and language. No significant differences werefound between normal controls and PD-SCD in any of the neuropsychological measures. Conversion to clinically diagnoseddementia during the follow-up was 50% in PD-MCI, 33.3% in PD-SCD and 14.3% in patients without subjective cognitivecomplaints. Discriminant function analyses and logistic regression analyses revealed that language domain and, especiallymemory domain are good predictors of dementia.Conclusions The present investigation is the first to conduct a long-term follow-up study of PD-SCD and its relationshipwith the development of dementia. The results provide relevant data about the characterization of SCD in PD patients andshow that PD-SCD is a risk factor for progression to dementia.
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/35390
UL http://riull.ull.es/xmlui/handle/915/35390
LA en
NO https://doi.org/10.1007/s00415-019-09197-0
DS Repositorio institucional de la Universidad de La Laguna
RD 24-nov-2024