RT info:eu-repo/semantics/article
T1 Health-related quality of life and depressive symptoms in Friedreich Ataxia
A1 Pérez Flores, Javier
A1 Hernández Torres, Atteneri
A1 Montón, Fernando
A1 Nieto Barco, Antonieta
A2 Psicología ClínicaPsicobiología y Metodología
A2 Grupo de investigación ULL: Neuropsicología
Facultad de Psicología y Logopedia
Instituto Universitario de Neurociencia
K1 Friedreich ataxia
K1 Cerebellum
K1 Quality of life
K1 Depression
K1 Neurological diseases
AB Purpose Friedreich ataxia (FRDA) is a chronic, progressive and highly disabling cerebellar degenerative disease. Despitethis, little attention has been paid to the health-related quality of life (HRQOL) in this disease. The aim of the present studywas to assess FRDA patients’ perception of HRQOL and to determine the infuence of depression, and demographic andclinical variables.Method The sample consisted of 62 patients with genetically confrmed FRDA. The SF-36 Health Survey was used to assessHRQOL. Depressive symptoms were evaluated with the Beck Depression Inventory-II.Results FRDA patients’ mean scores were signifcantly lower than the values for the Spanish population in all SF36 dimensions. Average z scores ranged from −5.5 in physical functioning to −0.48 in mental health. Age and clinical variableswere signifcant predictors of HRQOL in only several dimensions, whereas BDI scores were able to predict a signifcantpercentage of variance in all SF36 dimensions, except physical functioning.Conclusions Our study demonstrates the high impact of Friedreich ataxia on quality of life. This impact does not only occurin those aspects most related to motor disability but it is also present in non-motor dimensions. Depressive symptomatologyis the most relevant variable for predicting quality of life
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/35410
UL http://riull.ull.es/xmlui/handle/915/35410
LA en
NO https://doi.org/10.1007/s11136-019-02311-9
NO The final publication is available at link.springer.com
DS Repositorio institucional de la Universidad de La Laguna
RD 18-nov-2024