RT info:eu-repo/semantics/article
T1 The role of gender differences and menopause in obesity-related renal disease, renal inflammation and lipotoxicity
A1 Pérez Pérez, José Antonio
A1 Afonso-Alí, Aaron
A1 Porrini, Esteban
A1 Teixido Trujillo, Silvia
A1 Luis Lima, Sergio
A1 Acosta González, Nieves Guadalupe
A1 Sosa Paz, Irene
A1 Díaz Martín, Laura
A1 Rodríguez González, Covadonga
A1 Rodríguez Rodríguez, Ana Elena
A2 Biología Animal y Edafología y Geología
A2 Grupo de investigación NUTRAHLIPIDS
K1 obesity
K1 renal disease
K1 inflammation
K1 lipotoxicity
K1 menopause
AB The pathogenesis of obesity-related-renal disease is unknown. Menopause can promoterenal disease in obese women, but this interaction is unclear. In a previous study, we observedthat obese male and female mice developed albuminuria, hyperfiltration, and glomerulomegaly,and these changes were more severe in those obese ovariectomized females. In this study, we alsoevaluated renal inflammation and lipotoxicity in that animal model. For six months, 43 males and36 females C57BL6/J mice were randomized to standard diet (SD) or high fat diet (HFD). A group offemale animals on SD or HFD was ovariectomized to simulate menopause. We evaluated cytokines:NF-κβ p65, IL-1β, MCP-1, TNF-α, total lipid content, lipid classes, and fatty acid profile in totallipid and individual lipid classes in renal tissue and urine. We found that obese males and femalesshowed higher NF-kβ p-65, TNF-α and MCP-1 in renal tissue, and obese females ovariectomizedhad higher IL-1β and TNF-α compared with not-ovariectomized. Also, obese animals showedlower proinflammatory and higher anti-inflammatory fatty acids in kidney total lipids, while obesefemales ovariectomized had a more exacerbated pattern. In brief, obesity induces inflammationand an unbalanced lipidic profile in renal tissue. This pattern seems to be enhanced in obesityafter menopause.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/35411
UL http://riull.ull.es/xmlui/handle/915/35411
LA en
NO https://doi.org/10.3390%2Fijms241612984
DS Repositorio institucional de la Universidad de La Laguna
RD 10-may-2024