RT info:eu-repo/semantics/article
T1 Effects of dietary n-3 LCPUFA supplementation on the hippocampus of aging female mice: Impact on memory, lipid raft-associated glutamatergic receptors and neuroinflammation
A1 Pérez Pérez, José Antonio
A1 Taoro González, Lucas
A1 Pereda de Pablo, Daniel
A1 Valdés Baizábal, Catalina
A1 González Gómez, Miriam
A1 Mesa-Herrera, Fátima
A1 Canerina-Amaro, Ana
A1 Pérez González, Herminia
A1 Rodríguez González, Covadonga
A1 Díaz, Mario
A1 Marín, Raquel
K1 Long-chain polyunsaturated
K1 Fatty acids supplementation
K1 Lipid rafts
K1 Diet
K1 Hippocampus
K1 Neuroinflammation
K1 Memory
AB : Long-chain polyunsaturated fatty acids (LCPUFA), essential molecules whose precursorsmust be dietary supplied, are highly represented in the brain contributing to numerous neuronal processes. Recent findings have demonstrated that LCPUFA are represented in lipid raft microstructures,where they favor molecular interactions of signaling complexes underlying neuronal functionality.During aging, the brain lipid composition changes affecting the lipid rafts’ integrity and protein signaling, which may induce memory detriment. We investigated the effect of a n-3 LCPUFA-enricheddiet on the cognitive function of 6- and 15-months-old female mice. Likewise, we explored theimpact of dietary n-3 LCPUFAs on hippocampal lipid rafts, and their potential correlation withaging-induced neuroinflammation. Our results demonstrate that n-3 LCPUFA supplementationimproves spatial and recognition memory and restores the expression of glutamate and estrogenreceptors in the hippocampal lipid rafts of aged mice to similar profiles than young ones. Additionally, the n-3 LCPUFA-enriched diet stabilized the lipid composition of the old mice’s hippocampallipid rafts to the levels of young ones and reduced the aged-induced neuroinflammatory markers.Hence, we propose that n-3 LCPUFA supplementation leads to beneficial cognitive performanceby “rejuvenating” the lipid raft microenvironment that stabilizes the integrity and interactions ofmemory protein players embedded in these microdomains.
SN 1422-0067
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/35431
UL http://riull.ull.es/xmlui/handle/915/35431
LA en
NO https://doi.org/10.3390%2Fijms23137430
DS Repositorio institucional de la Universidad de La Laguna
RD 10-may-2024