RT info:eu-repo/semantics/article T1 Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment. A1 Acebes Vindel, Ángel José A1 Guebel, Daniel V. A1 Torres, Néstor V. K1 Vascular remodeling K1 Sprouting angiogenesis, K1 Atherosclerosis K1 Vascular inflammation K1 Capillary arterialization K1 Splice forms K1 Microarray AB Compromise of the vascular system has important consequences oncognitive abilities and neurodegeneration. The identification of themain molecular signatures present in the blood vessels of humanhippocampus could provide the basis to understand and tackle thesepathologies. As direct vascular experimentation in hippocampus isproblematic, we achieved this information by computationallydisaggregating publicly available whole microarrays data of humanhippocampal homogenates. Three conditions were analyzed: ‘YoungAdults’, ‘Aged’, and ‘aged with Mild Cognitive Impairment’ (MCI). Thegenes identified were contrasted against two independent data-sets.Here we show that the endothelial cells from the Younger Groupappeared in an ‘activated stage’. In turn, in the Aged Group, theendothelial cells showed a significant loss of response to shearstress, changes in cell adhesion molecules, increased inflammation,brain-insulin resistance, lipidic alterations, and changes in theextracellular matrix. Some specific changes in the MCI group werealso detected. Noticeably, in this study the features arisen from theAged Group (high tortuosity, increased bifurcations, and smoothmuscle proliferation), pose the need for further experimentalverification to discern between the occurrence of arteriogenesisand/or vascular remodeling by capillary arterialization. YR 2021 FD 2021 LK http://riull.ull.es/xmlui/handle/915/35807 UL http://riull.ull.es/xmlui/handle/915/35807 LA en DS Repositorio institucional de la Universidad de La Laguna RD 04-oct-2024