RT info:eu-repo/semantics/article
T1 Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment.
A1 Acebes Vindel, Ángel José
A1 Guebel, Daniel V.
A1 Torres, Néstor V.
K1 Vascular remodeling
K1 Sprouting angiogenesis,
K1 Atherosclerosis
K1 Vascular inflammation
K1 Capillary arterialization
K1 Splice forms
K1 Microarray
AB Compromise of the vascular system has important consequences oncognitive abilities and neurodegeneration. The identification of themain molecular signatures present in the blood vessels of humanhippocampus could provide the basis to understand and tackle thesepathologies. As direct vascular experimentation in hippocampus isproblematic, we achieved this information by computationallydisaggregating publicly available whole microarrays data of humanhippocampal homogenates. Three conditions were analyzed: ‘YoungAdults’, ‘Aged’, and ‘aged with Mild Cognitive Impairment’ (MCI). Thegenes identified were contrasted against two independent data-sets.Here we show that the endothelial cells from the Younger Groupappeared in an ‘activated stage’. In turn, in the Aged Group, theendothelial cells showed a significant loss of response to shearstress, changes in cell adhesion molecules, increased inflammation,brain-insulin resistance, lipidic alterations, and changes in theextracellular matrix. Some specific changes in the MCI group werealso detected. Noticeably, in this study the features arisen from theAged Group (high tortuosity, increased bifurcations, and smoothmuscle proliferation), pose the need for further experimentalverification to discern between the occurrence of arteriogenesisand/or vascular remodeling by capillary arterialization.
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/35807
UL http://riull.ull.es/xmlui/handle/915/35807
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 22-nov-2024