RT info:eu-repo/semantics/article
T1 Deciphering tacrolimus-induced toxicity in pancreatic ß-cells.
A1 Acebes Vindel, Ángel José
A1 Triñanes, J.
A1 Rodríguez Rodríguez, A.E.
A1 Brito Casillas, Y.
A1 Wagner, A.
A1 De Vries, A.P.J.
A1 Cuesto, G.
A1 Salido, E.
A1 Torres, A.
A1 Porrini, E.
K1 Pancreatic b Cells
K1 Toxicity
K1 Tacrolimus-Induced
AB b Cell transcription factors such as fork head box proteinO1(FoxO1), v-maf musculoaponeurotic fibrosarcoma oncogene homologA (MafA), pancreatic and duodenal homeobox1, and neuronal differentiation 1, are dysfunctional in type 2 diabetes mellitus (T2DM). Posttransplant diabetes mellitus resembles T2DMandreflectsinteractionbetweenpretransplant insulin resistanceand immunosuppressants ,mainly calcineurininhibitors(CNIs).We evaluated the effect of tacrolimus(TAC),cyclosporineA(CsA),and metabolic stressors (glucose plus palmitate) on insulinomab cells invitro and in pancreata of obeseand lean Zucker rats.Cellswereculturedfor5dayswith 100lMpalmitateand22mMglucose;CsA(250ng/ mL)orTAC(15ng/mL)were added in the last48h.
SN 2829–2840
YR 2017
FD 2017
LK http://riull.ull.es/xmlui/handle/915/35809
UL http://riull.ull.es/xmlui/handle/915/35809
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 06-ago-2024