RT info:eu-repo/semantics/article
T1 In vitro activity of 1H-phenalen-1-one derivatives against Leishmania spp. and evidence of programmed cell death.
A1 López Arencibia, Atteneri
A1 Reyes‑Batlle, María
A1 Freijo, Mónica B.
A1 Sifaou,  Ines
A1 Bethencourt‑Estrella, Carlos J.
A1 Rizo‑Liendo, Aitor
A1 Chiboub, Olfa
A1 McNaughton‑Smith, Grant
A1 Lorenzo‑Morales, Jacob
A1 Abad-Grillo, Teresa
A1 Piñero, José E.
K1 Leishmania donovani
K1 Leishmania amazonensis
K1 Phenalenones
K1 Chemotherapy
K1 Apoptosis-like
AB Background: The in vitro activity against Leishmania spp. of a novel group of compounds, phenalenone derivatives,is described in this study. Previous studies have shown that some phenalenones present leishmanicidal activity, andinduce a decrease in the mitochondrial membrane potential in L. amazonensis parasites, so in order to elucidate theevidence of programmed cell death occurring inside the promastigote stage, diferent assays were performed in twodiferent species of Leishmania.Methods: We focused on the determination of the programmed cell death evidence by detecting the characteristicfeatures of the apoptosis-like process, such as phosphatidylserine exposure, mitochondrial membrane potential, andchromatin condensation among others.Results: The results showed that four molecules activated the apoptosis-like process in the parasite. All the signalsobserved were indicative of the death process that the parasites were undergoing.Conclusions: The present results highlight the potential use of phenalenone derivatives against Leishmania speciesand further studies should be undertaken to establish them as novel leishmanicidal therapeutic agents.
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/35835
UL http://riull.ull.es/xmlui/handle/915/35835
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 17-may-2024