RT info:eu-repo/semantics/article
T1 Toxic effects of selected proprietary dry eye drops on Acanthamoeba
A1 López Arencibia, Atteneri
A1 Sifaoui, Inés
A1 Reyes Batlle, María
A1 Chiboub, Olfa
A1 Rodríguez Martín, Javier
A1 Rocha Cabrera, Pedro
A1 Valladares Hernández, Basilio
A1 Piñero, José E
A1 Lorenzo Morales, Jacob
A2 Obstetricia y GinecologíaPediatría, Medicina Preventiva y Salud Pública, Toxicología y Medicina Legal y Forense y Parasitología
K1 Toxic efects
K1 Acanthamoeba
AB Amoebae of the genus Acanthamoeba are ubiquitous protists that have been isolated from many sources such as soils, water and the air. They are responsible for infections including fatal encephalitis and a severe keratitis in humans. To date, there is no satisfactorily efective therapeutic agent againstthis pathogen and the infections it causes are exacerbated by the existence of a resistant cyst stage produced by this amoeba. As dry eye syndrome is a risk factor for Acanthamoeba keratitis, we aimed to evaluate the anti-Acanthamoeba activity of a variety of proprietary eye drops intended to treat dryeye syndrome. From the nine eye drop formulations tested, “Systane Ultra” was determined to be the most active against all tested Acanthamoeba strains. During our investigations into the mode of action of Systane Ultra, we discovered that it decreases mitochondrial membrane potential and ATP levels, induces chromatin condensation, and increases the permeability of the plasma-membrane.
PB Springer Nature
YR 2018
FD 2018
LK http://riull.ull.es/xmlui/handle/915/35836
UL http://riull.ull.es/xmlui/handle/915/35836
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 24-nov-2024