RT info:eu-repo/semantics/article
T1 Antibacterial properties of Phenolic triterpenoids against staphylococcus epidermidis
A1 León Guerra, Leandro Jesús
A1 López, Manuel R.
A1 Moujir, Laila
K1 pristimerol
K1 8‑epi‑6‑deoxoblepharodol
K1 Celastraceae
K1 Staphylococcus epidermidis
K1 antibacterial activity
K1 membrane disruption
AB Two phenolic triterpenoids, pristimerol (30 µg/mL) and 8-epi-6-deoxoblepharodol (20 µg/mL), obtained by catalytic reduction ofpristimerin, exhibited bacteriostatic action against Staphylococcus epidermidis. This activity was not dependent on the inoculumsize and the growth phase although it showed a stronger effectwhen cells were growing actively. Addition of phenolic triterpenoids to S. epidermidis cultures in the log-phase of growth led toan inhibitory effect on incorporation and uptake of radiolabeledprecursors thymidine, uridine, leucine, and N-acetyl-glucosamine after 30 min of treatment. Furthermore, a clear release ofUV-absorbing material and leakage of intracellular potassiumwere also detected. These findings, coupled with the high lipophilicity of these molecules, shown by high ClogP values, suggestthat 8-epi and pristimerol are able to interact within the lipid bilayer and as a consequence cause functional alterations on thecytoplasmic membrane of S. epidermidis cells.
YR 2011
FD 2011
LK http://riull.ull.es/xmlui/handle/915/35853
UL http://riull.ull.es/xmlui/handle/915/35853
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 12-jul-2024