RT info:eu-repo/semantics/article
T1 Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach
A1 Zeouk, Ikrame
A1 Sifaoui, Ines
A1 Ben Jalloul, Amel
A1 Bekhti, Khadija
A1 López Bazzocchi, Isabel
A1 Piñero Barroso, José Enrique
A1 Jiménez Díaz, Ignacio Antonio
A1 Lorenzo Morales, Jacob
K1 Bioguided fractionation
K1 Inula viscosa
K1 Taxifolin
K1 Quercetin
K1 Antioxidants
AB Oxidative stress is linked to several invasive diseases which causes significant clinical and economic impact,therefore, there is a need to develop new antioxidants. The natural products could play an important role inovercoming the current need. In the present work, the antioxidant bioassay-guided fractionation of the ethanolicextract of Inula viscosa leaves (Asteraceae) was performed using DPPH and ABTS assays affording three knowncompounds, which were successfully characterized as ilicic acid (1), taxifolin (2) and quercetin (3) based on 1D,2D NMR. Compounds 2 and 3 were identified as the most active, displaying similar or higher potency againstABTS (value 41.27 for quercetin and 142.58 for taxifolin) and similar activity against DPPH (value 41.27 forquercetin and 142.58 for taxifolin) than the well-known reference, ascorbic acid (value 65.36 for quercetin and58.43 for taxifolin) but less potency than the standard gallic acid. The discussion of SAR of the antioxidantpotential revealed that the type of natural product is crucial for the activity and the substitution pattern on theflavonoid skeleton modulate the antioxidant profile. Our findings show that I. viscosa leaves may be a naturalsource of antioxidants and once again the role of flavonoids health benefits is more strongly endorsed.
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/35927
UL http://riull.ull.es/xmlui/handle/915/35927
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 17-may-2024