RT info:eu-repo/semantics/article
T1 High oxygen concentrations inhibit Acanthamoeba spp.
A1 Sifaoui, Ines
A1 Capote Yanes, Eulalia
A1 Reyes Batlle, María
A1 Rodríguez Expósito, Rubén L.
A1 López Bazzocchi, Isabel
A1 Jiménez Díaz, Ignacio Antonio
A1 Piñero Barroso, José Enrique
A1 Lorenzo Morales, Jacob
A1 Weaver, Lindell K.
K1 Acanthamoeba spp
K1 Viability
K1 Reactive oxygen species
K1 Oxygen therapy
AB Efficacious treatments against Acanthamoeba Keratitis (AK) is challenging, often ineffective and linked to the intragenotypevariation in the drug efficacy. Increased oxygen can facilitate host response and can inhibit some organisms. Herein, wereport the effect of increased oxygen concentrations on Acanthamoeba spp. growth and its effect on ROS (reactive oxygenspecies) production. The exposition to pure oxygen could reduce cell growth by at least 60% for Acanthamoeba castellaniiNeff, Acanthamoeba polyphaga, and Acanthamoeba griffini. The increase in ROS production confirming that oxygen cell’sgrowth inhibition was due to oxidative stress. Further studies are needed to determine oxygen saturation level, time of oxygenexposition, and number of sessions needed to eliminate the parasite.
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/35933
UL http://riull.ull.es/xmlui/handle/915/35933
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 17-may-2024