RT info:eu-repo/semantics/article
T1 Intra-combined antioxidant activity and chemical characterization of three fractions from Rhamnus alaternus extract: Mixture design
A1 Zeouk, Ikrame
A1 Ouedrhiri, Wessal
A1 Jiménez Díaz, Ignacio Antonio
A1 Lorenzo Morales, Jacob
A1 López Bazzocchi, Isabel
A1 Bekhti, Khadija
K1 Antioxidant
K1 Rhamnus alaternus
K1 Flavonoids
K1 Anthraquinones
K1 Mixture design
K1 Synergism
K1 Formulation
AB The look for benefits antioxidant agents has attracted much attention from consumers, health and food industries.Certainly, the interactions occurring between different compounds affect the antioxidant efficiency. Thecurrent study aims the investigation of the antioxidant combined effect of Rhamnus alaternus fractions usingDPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay. The three most active fractions were subject for binaryand ternary combinations using the augmented simplex-centroid design. Two known compounds emodin (1) andkaempferol (2) were identified from the ethanolic extract of the leaves of Rhamnus alaternus. Their structureswere elucidated using spectroscopy data. The antioxidant potent of the crude extract and the mixture wascompared with the antioxidant activity of the fractions separately. Important synergetic effects were observed inbinary mixture between the most active fractions, besides the response optimizer allowed us to optimize themixture presenting the highest antioxidant activity at 82.54 %. The results from the present work could haveinteresting applications in both medical formulations and functional food design.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/35938
UL http://riull.ull.es/xmlui/handle/915/35938
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 06-ago-2024