RT info:eu-repo/semantics/article
T1 Structural Requirements for Antimicrobial Activity of Phenolic Nor-Triterpenes from Celastraceae Species
A1 Moujir, Laila
A1 López, Manuel R.
A1 Reyes, Carolina P.
A1 Jiménez Díaz, Ignacio Antonio
A1 López Bazzocchi, Isabel
K1 Maytenus
K1 celastroloids
K1 semisynthesis
K1 antibacterial activity
K1 structure–activity relationship
AB The emergence of pathogenic bacteria-resistant strains is a major public health issue.In this regard, natural product sca olds o er a promising source of new antimicrobial drugs.In the present study, we report the antimicrobial activity against Gram-positive and Gram-negativebacteria and the yeast Candida albicans of five phenolic nor-triterpenes (1–5) isolated from Maytenusblepharodes and Maytenus canariensis in addition to four derivatives (6–9), three of them reported forthe first time. Their stereostructures have been elucidated on the basis of spectroscopic analysis,including one-dimensional (1D) and two-dimensional (2D) NMR techniques, spectrometric methods,and comparison with data reported in the literature. To understand the structural basis for theantimicrobial activity of this type of compounds, we have performed an in-depth study of thestructure–activity relationship (SAR) of a series of previously reported phenolic nor-triterpenes.The SAR analysis was based on the skeleton framework, oxidation degree, functional groups, andregiosubstitution patterns, revealing that these aspects modulate the antimicrobial activity.
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/36063
UL http://riull.ull.es/xmlui/handle/915/36063
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 12-jul-2024