RT info:eu-repo/semantics/article
T1 An unprecedented chlorine-containing piperamide from Piper pseudoarboreum as potential leishmanicidal agent
A1 Flores, Ninoska
A1 Ticona, Juan C.
A1 Bilbao Ramos, Pablo
A1 Dea Ayuela, M. Auxiliadora
A1 Ruiz Macedo, Juan C.
A1 López Bazzocchi, Isabel
A1 Bolás Fernández, Francisco
A1 Jiménez Díaz, Ignacio Antonio
K1 Piper pseudoarboreum
K1 Chlorinated-piperamide
K1 Biosynthetic pathway
K1 Leishmanicidal
AB A phytochemical investigation of the ethanolic extract of leaves from Piper pseudoarboreum led to the isolation of3-chlorosintenpyridone 1, an unprecedented chlorinated piperamide, together with the known compounds 2–12.Their structures were established based on 1D and 2D (COSY, ROESY, HMQC, and HMBC) NMR spectroscopy, inaddition to high resolution mass spectrometry. The proposed biosynthetic pathway of compound 1 is discussed.Compounds 1–12 were tested in vitro for their leishmanicidal potential against promastigote stages of Leishmaniaamazonensis, L braziliensis, L. guyanensis and L. infantum. Two compounds from this series, the alkamide 1 (IC503.4–5.2 μM) and the fatty acid 9 (IC50 18.7–29.6 μM) displayed higher or similar potency to Miltefosine, used asthe reference drug.
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/36064
UL http://riull.ull.es/xmlui/handle/915/36064
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 11-may-2024