RT info:eu-repo/semantics/article
T1 Alginate-hydrogel versus alginate-solid system. Efficacy in bone regeneration in osteoporosis.
A1 Delgado Hernández, Araceli Rita
A1 García García, Patricia
A1 Reyes, Ricardo
A1 Pérez Herrero, Edgar
A1 Arnau, María Rosa
A1 Evora, Carmen
K1 Scaffold
K1 BMP-2
K1 β-Estradiol
K1 Osteoporosis
K1 Bone regeneration
K1 Mesenchymal stem cells
AB In the present study, two different PLGA-Alginate scaffolds, a hydrogel (HY) and a solid sponge (SS), were developed for β-estradiol and BMP-2 sustained delivery for bone regeneration in osteoporosis. β-Estradiol and BMP-2 were encapsulated in PLGA and PLGA-Alginate microspheres respectively. Scaffolds were characterized in vitro in terms of porosity, water uptake, release rate and HY rheological properties. BMP-2 release profiles were also analysed in vivo. The bone regeneration induced by both HY and SS was evaluated using a critical-sized bone defect in an osteoporotic (OP) rat model. Compared to HY, SS presented 30% higher porosity, more than double water absorption capacity and almost negligible mass loss compared to the 40% of HY. Both systems were flexible and fit well the defect shape, however, HY has the advantage of being injectable. Despite both delivery systems had similar composition and release profile, bone repair was around 30% higher with SS than with HY, possibly due to its longer residence time at the defect site. The incorporation of mesenchymal stem cells obtained from OP rats did not result in any improvement or synergistic effect on bone repair.
SN 0928-4931
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/36135
UL http://riull.ull.es/xmlui/handle/915/36135
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 10-may-2024