RT info:eu-repo/semantics/article
T1 Autophagy inhibition as a promising therapeutic target for laryngeal cancer
A1 Garcia-Mayea, Yoelsis
A1 Mir Pérez, Cristina
A1 Muñoz-Hidalgo, Lisandra
A1 Benavente, Sergi
A1 Castellvi, Josep
A1 Temprana, Jordi
A1 Maggio, Valentina
A1 Lorente, Juan
A1 Paciucci, Rosanna
A1 Lleonart, Matilde E.
K1 Laryngeal cancer
K1 Autophagy inhibition
AB To identify the putative relevance of autophagy in laryngeal cancer, we performed an immunohistochemistry study to analyze the expression of the proteins involved in this process, namely, LC3, ATG5 and p62/SQSTM1. Additionally, Prostate tumor-overexpressed gene 1 protein (PTOV1) was included due to its potential relevance in laryngeal cancer. Moreover, as cancer resistance might involve autophagy in some circumstances, we studied the intrinsic drug resistance capacity of primary tumor cultures derived from 13 laryngeal cancer biopsies and their expression levels of LC3, ATG5, p62 and PTOV1. Overall, our results suggest that (i) cytoplasmic p62 and PTOV1 can be considered prognostic markers in laryngeal cancer, (ii) the acquisition of resistance seems to be related to PTOV1 and autophagy-related protein overexpression, (iii) by increasing autophagy, PTOV1 might contribute to resistance in this model and (iv) the expression of autophagy-related proteins could classify a subgroup of laryngeal cancer patients who will benefit from a therapy based upon autophagy inhibition. Our study suggests that autophagy inhibition with hydroxychloroquine could be a promising strategy for laryngeal cancer patients, particularly those patients with high resistance to the CDDP treatment that in addition have autophagy upregulation.
SN 1460-2180
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/36161
UL http://riull.ull.es/xmlui/handle/915/36161
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 24-nov-2024